theoretical-foundations
This document explains the mathematical and statistical principles underlying scvi-tools.
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# Theoretical Foundations of scvi-tools
This document explains the mathematical and statistical principles underlying scvi-tools.
## Core Concepts
### Variational Inference
**What is it?**
Variational inference is a technique for approximating complex probability distributions. In single-cell analysis, we want to understand the posterior distribution p(z|x) - the probability of latent variables z given observed data x.
**Why use it?**
- Exact inference is computationally intractable for complex models
- Scales to large datasets (millions of cells)
- Provides uncertainty quantification
- E
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