target_annotations
Open Targets defines a target as "any naturally-occurring molecule that can be targeted by a medicinal product." Targets are primarily protein-coding genes identified by Ensembl gene IDs, but also include RNAs and pseudogenes from…
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- Scientific
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What it does and how to use it
A skill that teaches Claude Code to do scientific tasks well. It is packaged knowledge the model uses whenever it is relevant.
- Install the skill (command above).
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Install (Claude Code)
mkdir -p .claude/skills/target-annotations && curl -fsSL https://doutorai.pt/data/lib/skills__target-annotations.md -o .claude/skills/target-annotations/SKILL.mdPaste this command into the terminal, in your project folder, and the component installs automatically.
Content
# Target Annotations and Features
## Overview
Open Targets defines a target as "any naturally-occurring molecule that can be targeted by a medicinal product." Targets are primarily protein-coding genes identified by Ensembl gene IDs, but also include RNAs and pseudogenes from canonical chromosomes.
## Core Target Annotations
### 1. Tractability Assessment
Tractability evaluates the druggability potential of a target across different modalities.
#### Modalities Assessed:
**Small Molecule**
- Prediction of small molecule druggability
- Based on structural features, chemical precedence
- B
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