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rules_catalog

Comprehensive catalog of all available medicinal chemistry rules, structural alerts, and filters in medchem.

  • Skills
  • Scientific
  • 0

What it does and how to use it

A skill that teaches Claude Code to do scientific tasks well. It is packaged knowledge the model uses whenever it is relevant.

  1. Install the skill (command above).
  2. In Claude Code, describe what you need - the skill turns on by itself when the context fits.
  3. No commands to memorize: you talk in plain language and the skill does the rest.

Install (Claude Code)

mkdir -p .claude/skills/rules-catalog && curl -fsSL https://doutorai.pt/data/lib/skills__rules-catalog.md -o .claude/skills/rules-catalog/SKILL.md

Paste this command into the terminal, in your project folder, and the component installs automatically.

Content

# Medchem Rules and Filters Catalog

Comprehensive catalog of all available medicinal chemistry rules, structural alerts, and filters in medchem.

## Table of Contents

1. [Drug-Likeness Rules](#drug-likeness-rules)
2. [Lead-Likeness Rules](#lead-likeness-rules)
3. [Fragment Rules](#fragment-rules)
4. [CNS Rules](#cns-rules)
5. [Structural Alert Filters](#structural-alert-filters)
6. [Chemical Group Patterns](#chemical-group-patterns)

---

## Drug-Likeness Rules

### Rule of Five (Lipinski)

**Reference:** Lipinski et al., Adv Drug Deliv Rev (1997) 23:3-25

**Purpose:** Predict oral bioavaila

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