models-multimodal

This document covers models for joint analysis of multiple data modalities in scvi-tools.

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Scientific
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Content

# Multimodal and Multi-omics Integration Models

This document covers models for joint analysis of multiple data modalities in scvi-tools.

## totalVI (Total Variational Inference)

**Purpose**: Joint analysis of CITE-seq data (simultaneous RNA and protein measurements from same cells).

**Key Features**:
- Jointly models gene expression and protein abundance
- Learns shared low-dimensional representations
- Enables protein imputation from RNA data
- Performs differential expression for both modalities
- Handles batch effects in both RNA and protein layers

**When to Use**:
- Analyzing CITE-se

- 🔒 Full content on the Pro plan (€7.99/month) -

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